What are sex linked genetic disorders

This diversity protects the human race from being wiped out by a single kind of medical problem. She passed the harmful allele for this X-linked trait on to one of her four sons and at least two of her five daughters.

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But in females, where the Z chromosome does not recombine, the two alleles always pass to offspring together. In women, a recessive allele on one X chromosome is often masked in their phenotype by a dominant normal allele on the other.

Female mammals make eggs, which always have an X chromosome. Dominant XLGD's include conditions such as Albright's hereditary osteodystrophy seizures, mental retardation, stunted growth , Goltz's syndrome mental retardation , cylindromatosis deafness and upper body tumors , oral-facial-digital syndrome no teeth, cleft tongue, some mental retardation , and incontinentia pigmenti abnormal swirled skin pigmentation. They may already have had children of their own and transmitted the genetic trait that caused their disorder to their offspring.

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Sex-linked recessive

Conditions resulting from mutations in mitochondrial DNA can appear in every generation of a family and can affect both males and females, but fathers do not pass these disorders to their daughters or sons. This statement is misleading, and only applies to MALE children: If the disorder is transmitted by genes inherited from only one parent, it is said to be an autosomal dominant disorder.
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